Insulin Resistance
a reduced sensitivity to insulin, meaning that more insulin must be released to cause a given amount of nutrients uptake into the body's cells. Note that the downregulation of insulin sensitivity is likely to be more extreme in lean tissue than adipose tissue , so that persons who have developed a high degree of insulin resistance are likely to preferentially store nutrients as fat rather than use them for tissue growth and repair. type-II (adult onset) diabetes is an extreme form of insulin resistance.